WO2012172343A3 - Traitement de l'angiocholite sclérosante primitive - Google Patents
Traitement de l'angiocholite sclérosante primitive Download PDFInfo
- Publication number
- WO2012172343A3 WO2012172343A3 PCT/GB2012/051353 GB2012051353W WO2012172343A3 WO 2012172343 A3 WO2012172343 A3 WO 2012172343A3 GB 2012051353 W GB2012051353 W GB 2012051353W WO 2012172343 A3 WO2012172343 A3 WO 2012172343A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chemokine receptor
- sclerosing cholangitis
- primary sclerosing
- treating primary
- ccr7
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
Abstract
L'invention concerne une méthode de traitement de l'angiocholite sclérosante primitive consistant à appliquer du sang périphérique d'un patient ou sujet sur une colonne d'aphérèse chargée d'un support solide comprenant un ou plusieurs réactifs de liaison pouvant se lier spécifiquement à un récepteur de chimiokines, éventuellement le récepteur de chimiokines CCR9, CXCR4, CCR7 ou CCR5, immobilisé directement ou indirectement sur le support, éliminant ainsi au moins un récepteur de chimiokines, éventuellement des cellules exprimant CCR9, CXCR4, CCR7 et CCR5 à partir du sang périphérique du patient ou sujet. L'invention concerne en outre diverses méthodes thérapeutiques associées, ainsi que des réactifs de liaison utiles.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/105,628 US9726666B2 (en) | 2011-06-13 | 2013-12-13 | Diagnosing and treating inflammatory diseases |
US15/629,705 US10429385B2 (en) | 2011-06-13 | 2017-06-21 | Treating conditions associated with sepsis |
US15/629,713 US10408832B2 (en) | 2011-06-13 | 2017-06-21 | Treating mental disorders |
US15/629,700 US10422800B2 (en) | 2011-06-13 | 2017-06-21 | Treating respiratory conditions |
US15/629,691 US10451620B2 (en) | 2011-06-13 | 2017-06-21 | Treating conditions associated with metabolic syndrome |
US15/629,697 US10502736B2 (en) | 2011-06-13 | 2017-06-21 | Treating multiple sclerosis |
US15/629,708 US10401357B2 (en) | 2011-06-13 | 2017-06-21 | Treating cancer |
US16/537,224 US20190361020A1 (en) | 2011-06-13 | 2019-08-09 | Treating respiratory conditions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161496329P | 2011-06-13 | 2011-06-13 | |
US61/496,329 | 2011-06-13 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2012/051356 Continuation-In-Part WO2012172346A2 (fr) | 2011-06-13 | 2012-06-13 | Traitement de maladies respiratoires |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2012/051346 Continuation-In-Part WO2012172337A2 (fr) | 2011-06-13 | 2012-06-13 | Traitement de maladie cardiovasculaire |
US14/105,628 Continuation-In-Part US9726666B2 (en) | 2011-06-13 | 2013-12-13 | Diagnosing and treating inflammatory diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012172343A2 WO2012172343A2 (fr) | 2012-12-20 |
WO2012172343A3 true WO2012172343A3 (fr) | 2013-03-07 |
Family
ID=46317439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2012/051353 WO2012172343A2 (fr) | 2011-06-13 | 2012-06-13 | Traitement de l'angiocholite sclérosante primitive |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012172343A2 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
GB202012451D0 (en) * | 2020-08-11 | 2020-09-23 | Univ Newcastle | Biomarkers in primary biliary cholangitis |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030017979A1 (en) * | 1999-03-11 | 2003-01-23 | Matthias Mack | Antibody and chemokine constructs and their use in the treatment of infections and immunological diseases |
DE102005036505A1 (de) * | 2004-07-30 | 2006-06-01 | Adexter Gmbh | Vorrichtung und Verfahren zum Isolieren von Zellen, Biopartikeln und/oder Molekülen aus Flüssigkeiten mit dem Ziel einer Anwendung zur Behandlung von Krankheiten des Menschen |
WO2006126209A1 (fr) * | 2005-05-26 | 2006-11-30 | Rappaport Family Institute For Research In The Medical Sciences | Polypeptides, compositions les comprenant et procedes les utilisant pour le traitement des conditions medicales associees a cxcr4 |
WO2007133147A1 (fr) * | 2006-05-12 | 2007-11-22 | Ibd Column Therapies International Ab | Procédé et moyens pour traiter les maladies inflammatoires chroniques de l'intestin |
WO2010029317A2 (fr) * | 2008-09-10 | 2010-03-18 | Ibd Column Therapies International Ab | Traitement d’états inflammatoires |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2371849A1 (fr) | 1999-02-22 | 2000-08-31 | Millennium Pharmaceuticals, Inc. | Complexes constitues d'un anticorps et de chimiokines biotinylees |
SG193216A1 (en) | 2008-08-18 | 2013-09-30 | Amgen Fremont Inc | Antibodies to ccr2 |
-
2012
- 2012-06-13 WO PCT/GB2012/051353 patent/WO2012172343A2/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030017979A1 (en) * | 1999-03-11 | 2003-01-23 | Matthias Mack | Antibody and chemokine constructs and their use in the treatment of infections and immunological diseases |
DE102005036505A1 (de) * | 2004-07-30 | 2006-06-01 | Adexter Gmbh | Vorrichtung und Verfahren zum Isolieren von Zellen, Biopartikeln und/oder Molekülen aus Flüssigkeiten mit dem Ziel einer Anwendung zur Behandlung von Krankheiten des Menschen |
WO2006126209A1 (fr) * | 2005-05-26 | 2006-11-30 | Rappaport Family Institute For Research In The Medical Sciences | Polypeptides, compositions les comprenant et procedes les utilisant pour le traitement des conditions medicales associees a cxcr4 |
WO2007133147A1 (fr) * | 2006-05-12 | 2007-11-22 | Ibd Column Therapies International Ab | Procédé et moyens pour traiter les maladies inflammatoires chroniques de l'intestin |
WO2010029317A2 (fr) * | 2008-09-10 | 2010-03-18 | Ibd Column Therapies International Ab | Traitement d’états inflammatoires |
Non-Patent Citations (4)
Title |
---|
ANDREA T BORCHERS ET AL: "Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis", SEMINARS IN IMMUNOPATHOLOGY, SPRINGER, BERLIN, DE, vol. 31, no. 3, 17 June 2009 (2009-06-17), pages 309 - 322, XP019758214, ISSN: 1863-2300, DOI: 10.1007/S00281-009-0167-2 * |
B. EKSTEEN ET AL: "Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 200, no. 11, 6 December 2004 (2004-12-06), pages 1511 - 1517, XP055037419, ISSN: 0022-1007, DOI: 10.1084/jem.20041035 * |
GRANT ALLISTER J ET AL: "Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 4, April 2002 (2002-04-01), pages 1445 - 1455, XP002683083, ISSN: 0002-9440 * |
TERADA RYO ET AL: "Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PALHOLOGY, INC, vol. 83, no. 5, 1 May 2003 (2003-05-01), pages 665 - 672, XP008155843, ISSN: 0023-6837, DOI: DOI:10.1097/01.LAB.0000067498.89585.06 * |
Also Published As
Publication number | Publication date |
---|---|
WO2012172343A2 (fr) | 2012-12-20 |
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